Is Cialis Effective?

×
Content of this article

Over the past 20 years, there has been a revolution in the treatment and understanding of erectile dysfunction. The introduction of the first oral phosphodiesterase type 5 (PDE5) inhibitor, Viagra by Pfizer, in 1998 was a huge turning point in the treatment of erectile dysfunction.
Before Viagra, the treatment of erectile dysfunction was invasive and much less convenient. Treatment involved intracavernosal prostaglandin injections or intraurethral pellets. The invasive nature of this treatment meant it was not widely accepted by patients. To be effective the treatment had to be administered immediately before attempting sexual activity. The convenience of administration of oral PDE5 inhibitor treatment along with its duration of action was of enormous benefit to erectile dysfunction sufferers.
The massive advances in pharmacological treatment of erectile dysfunction has helped lead to the current understanding of the physiology of erection and the pathophysiology of erectile problems.
In 2003 two more PDE5 inhibitors became available on the market. These were Tadalafil, brand name Cialis, and Vardenafil, brand name Levitra.

Cialis & Tadalafil (As Needed)

From: £19.98

These three PDE5 inhibitors have similar mechanisms of action. They all increase blood flow to the penis during sexual stimulation. There are differences in duration of action, however. Tadalafil varies significantly from Sildenafil and Vardenafil in its half-life. Sildenafil and Vardenafil have half-lives of 4 hours while Tadalafil has a half-life of 17.5 hours in healthy men. This gives Cialis a much longer duration of action. Viagra is effective for up to 4 hours, Levitra is effective for up to 12 hours and Cialis is effective for up to 36 hours. The 36-hour therapeutic window of activity of Cialis gives patients more freedom in deciding the time of sexual activity. Some men may find this a benefit in having a positive impact on any performance anxiety.
In 2007 there were further developments in the treatment of erectile dysfunction with Cialis. The European Commission approved the treatment of erectile dysfunction with once-daily dosing of 2.5mg or 5mg Cialis. This once daily low dose tablet meant that men could attempt sex at any time between doses, with no need to plan sexual activity around a pill.

 

Click HERE to View Cialis Prices > >

 

How is the effectiveness of erectile dysfunction treatment assessed?

To evaluate the effectiveness of erectile dysfunction treatments studies most commonly use questionnaires or diaries. These give measurements which can be used to show the efficacy of the drug and any functional improvements in erectile function.
The International Index of Erectile Function-Erectile Function domain (IIEF-EF) one of the most extensively used measurements. It uses a questionnaire of 15 questions, with a score assigned to the answers given. The score ranges from 0 to 30 for the 15 questions. Two questions out of the fifteen can be used to further assess the effectiveness of the erectile dysfunction medication. Question 3 asks about ‘successful penile penetration’ and question 4 asks about ‘maintenance of erection after penetration’.
Another assessment measurement is the Sexual Encounter Profile (SEP). This is a diary that records a patient’s sexual experiences. The responses given by a patient can be used to evaluate the efficacy of the treatment.
The third commonly used measurement is the Global Assessment Question (GAQ). This shows the percentage of patients that report ‘yes’ to being asked ‘has the treatment improved erectile function?’

 

Is Cialis effective?

Clinical trials on Cialis have shown it to be effective in significantly increasing erectile functioning compared with placebo.
Studies take into consideration results obtained using the measurements discussed above. The International Index of Erectile Function-Erectile Function, the Sexual Encounter Profile, and the Global Assessment Question are used in presenting results of the studies to show the extent to which the treatment helped with erectile problems.
Several studies have been conducted using Cialis. The studies have looked at the treatment of erectile dysfunction in different groups of people including the general erectile dysfunction population, patients with difficult to treat erectile dysfunction, erectile dysfunction due to diabetes mellitus, and the effectiveness of once-daily dosage with Cialis.
Studies have shown that Cialis is safe and well tolerated. Cialis is effective in the general population of erectile dysfunction sufferers along with patients who have more severe erectile dysfunction or erectile dysfunction along with other comorbidities.

What will Cialis not help with?

Cialis is prescribed for the treatment of erectile dysfunction and has been shown to be efficacious in helping this problem. It is important to note which problem Cialis will not help with.
Cialis will not cure erectile dysfunction.
Cialis will not increase a man’s sexual desire.
Cialis does not give any protection from sexually transmitted diseases.
Cialis does not have any contraception properties.

Order erectile dysfunction treatment

Sildenafil

From: £16.00

Viagra

From: £45.00

Tadalafil

From: £19.98

Cialis

From: £39.99

How does Cialis increase erection function?

A penile erection involves a complex pathway of neural, vascular, hormonal, and psychological factors. Sexual stimulation leads to the release of the primary erectile-mediating neurotransmitter nitric oxide. Nitric oxide causes the relaxation of erectile smooth muscle and so increased penile blood flow, enabling an erection to occur.
Cialis increases erection function by facilitating and enhancing nitric oxide relaxation of erectile smooth muscle with sexual stimulation through its inhibition of cGMP in the penis tissue. There is an increase in blood flow to the penis during sexual stimulation allowing an erection to occur.

 

Is Cialis used for anything else as well as erection problems?

5 mg daily dose of Cialis can be used in the treatment of benign prostatic hyperplasia (BPH). It is common for men to suffer from both erectile dysfunction and benign prostatic hyperplasia. Estimates show that approximately half of the men with erectile dysfunction also suffer from BPH.
BPH is characterised by problematic urinary symptoms. In BPH men have an enlarged prostate gland. An enlarged prostate can cause problematic urinary symptoms such as needing to urinate frequently or urgently including excessive urination during the night, stopping and starting while urinating, needing to strain during urination, a weak urine stream and incomplete emptying of the bladder.

Cialis & Tadalafil (As Needed)

From: £19.98

Can anyone take Cialis?

Cialis is a prescription only medication. This means a Doctor must decide if treatment with Cialis is the most suitable and safe option before the medication is prescribed. Cialis is not suitable for everyone. A Doctor will be able to discuss alternative possibilities if Cialis is not suitable due to health issues or concurrent medication.
If any of the following health problems apply, Cialis may not be the most suitable treatment.

  • Angina, heart failure, irregular heartbeats, or heart attack
  • pulmonary hypertension
  • low blood pressure or high blood pressure that is not controlled
  • stroke
  • liver or kidney problems or require dialysis
  • retinitis pigmentosa
  • severe vision loss
  • stomach ulcers or a bleeding problem
  • a deformed penis shape / Peyronie’s disease
  • an erection that lasted more than 4 hours
  • blood cell problems.

It is important to discuss any current medication with the Doctor who will decide if Cialis is a safe and appropriate treatment. Certain medication should not be taken with Cialis. This medication includes: –
‘Nitrate’ medication such as isosorbide dinitrate or isosorbide mononitrate which are usually prescribed for angina. Nitrates are also found in recreational drugs known as ‘poppers’ in the form of amyl nitrate and butyl nitrate. If Cialis is taken alongside nitrate medication it can cause a dangerous drop in blood pressure.
‘Guanylate cyclase stimulators’. If Cialis is taken with this medication it can also cause a dangerous drop in blood pressure.

 

Any further questions about Cialis and its use in treating Erectile Dysfunction?

This article has covered issues associated with erectile dysfunction and information regarding Cialis or Tadalafil as a possible treatment option. If you have any further questions or concerns our Doctor and Pharmacist are available to answer these either via email or telephone.

 

Click HERE to View Cialis Prices > >

 

References:

  1. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3776492/
  2. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2643112/?report=classic
  3. https://www.pharmaceutical-journal.com/news-and-analysis/infographics/three-decades-of-viagra/20202847.article?firstPass=false
  4. https://www.ncbi.nlm.nih.gov/pubmed/12352386
  5. https://bnf.nice.org.uk/drug/tadalafil.html
  6. https://www.cialis.com/index.html

Assured Pharmacy is not liable for the currency or accuracy of the information contained in this blog post. For specific information about your personal medical condition, please contact our doctors or pharmacists for advice on [email protected]