What Side Effects Can I Expect From Taking Cialis?

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Cialis is one of the treatments for erectile dysfunction available here at Assured Pharmacy. To help our clients understand their medications and medical conditions, we’ve written a series of articles on our blog that will provide further information about different conditions and medications.
This article is about Cialis. We’ll cover what Cialis is, what it is used for, how to take it, who should not take it and any side effects you can expect from taking it.

Cialis & Tadalafil (As Needed)

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What is Cialis?

Cialis is the brand name for a medication known as Tadalafil. Each film−coated tablet of Cialis contains 2.5mg, 5mg, 10mg or 20mg Tadalafil. Each tablet also contains the active substance (excipient) Lactose (as monohydrate).

  • The 2.5 mg tablets are light orange-yellow and almond shaped tablets, marked ‘C 2 ½’ on one side. Each 2.5 mg film-coated tablet of Cialis contains 87 mg of lactose (as monohydrate).
  • The 5 mg tablets are light yellow and almond shaped tablets, marked ‘C 5′ on one side. Each 5 mg film-coated tablet of Cialis contains 121 mg of lactose (as monohydrate).
  • The 10 mg tablets are light yellow and almond shaped tablets, marked ‘C 10′ on one side. Each 10 mg film-coated tablet of Cialis contains 170 mg of lactose (as monohydrate).
  • The 20 mg tablets are yellow and almond shaped tablets, marked ‘C 20′ on one side. Each 20 mg film-coated tablet of Cialis contains 233 mg of lactose (as monohydrate).

 

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The other substances (excipients) in each film coated Cialis tablet (that are inactive) include:

 

Tablet core:

  • lactose monohydrate
  • croscarmellose sodium
  • hydroxypropyl cellulose
  • microcrystalline cellulose
  • sodium lauryl sulfate
  • magnesium stearate

2.5 mg Film-coat:

  • lactose monohydrate
  • hypromellose
  • triacetin
  • titanium dioxide (E171)
  • iron oxide yellow (E172)
  • iron oxide red (E172)
  • talc

5 mg, 10 mg and 20 mg Film-coat:

  • lactose monohydrate
  • hypromellose
  • triacetin
  • titanium dioxide (E171)
  • iron oxide yellow (E172)
  • talc

The legal category for Cialis is POM. This means it is a prescription only medicine and supply can only be made according to the instructions in a prescription issued by a qualified doctor or non-medical prescriber.
You should not buy this or any other prescription-only medication without first speaking to a duly qualified and registered healthcare professional.

 

What is Cialis used for?

Cialis (Tadalafil) is indicated for the treatment of Erectile Dysfunction in adult men aged 18 years and older. For Cialis to be effective, sexual stimulation is required.
Cialis is also indicated for the treatment of Benign Prostatic Hyperplasia and Pulmonary Arterial Hypertension. Treatment for Pulmonary Arterial Hypertension can only be initiated under the supervision of a medical specialist.

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How do I take Cialis?

The initial treatment dose for Erectile Dysfunction is 10 mg taken as a single dose when required at least 30 minutes before sexual activity. If the 10 mg dose does not produce an adequate effect and you do not experience any moderate or severe side effects, you may increase the dose to the maximum recommended dose of 20 mg per dose, with a maximum of one single dose per day. Subsequent doses should be adjusted according to how you respond to the medications and how you tolerate it. The effect of subsequent doses may last longer than 24 hours, so it is recommended that you do not take Cialis continuously every day.
The treatment dose for Benign Prostatic Hyperplasia is Cialis 5 mg once daily.
The treatment dose for Pulmonary Arterial Hypertension is Cialis 40 mg once daily.

 

Who should not take Cialis?

Cialis is licensed for use in adult men only aged 18 years and older for the treatment of Erectile Dysfunction, Benign Prostatic Hyperplasia and Pulmonary Arterial Hyperplasia.
Cialis is not licensed for use by women and children, so it should not be taken by women or children under the age of 18 years.
Adult men who are hypersensitive to the active ingredient Tadalafil or to any of the excipients, should not take Cialis.
As CIALIS contains lactose, patients with rare hereditary problems of galactose intolerance, the Lapp lactase deficiency or glucose-galactose malabsorption should not take this medicinal product.
Adult men with some pre-existing medical conditions or those taking certain classes of medications cannot take Cialis. Therefore, it is important for you to see a doctor to discuss your individual circumstances. You can either book a consultation with your regular GP or click here now so that you can have your clinical evaluation from the comfort of your home by having a remote consultation with our in-house doctor today.
It is important that during your consultation, you inform the doctor of all previous and existing conditions you have. You should also inform the doctor of all medications you are currently taking including herbal remedies and over the counter medications that you may have bought without needing a prescription. You should mention if you are allergic to any medication too or if there’s any medication you cannot or should not take for any reason whatsoever.
The list of conditions and the list of medications that may affect the suitability of use of Cialis for your individual circumstances are outside the scope of this article. That is why it is important for you to have an in-depth consultation with a doctor before treatment is initiated. This way, you minimise the risk of any side effects occurring.

 

What side effects can I expect from taking Cialis?

Below is further information about the undesirable effects that may be seen from taking Cialis as provided by the marketing authorisation holder of Cialis.

Summary of the safety profile:

The most commonly reported adverse reactions in patients taking CIALIS for the treatment of erectile dysfunction or benign prostatic hyperplasia were headaches, dyspepsia, back pain and myalgia, in which the incidences increase with increasing dose of CIALIS. The adverse reactions reported were transient, and generally mild or moderate. The majority of headaches reported with CIALIS once-a-day dosing are experienced within the first 10 to 30 days of starting treatment.

Tabulated summary of adverse reactions

The table below lists the adverse reactions observed from spontaneous reporting and in placebo-controlled clinical trials (comprising a total of 8022 patients on CIALIS and 4422 patients on placebo) for on-demand and once-a-day treatment of erectile dysfunction and the once-a-day treatment of benign prostatic hyperplasia.
Frequency convention: Very common (≥1/10), Common (≥1/100 to <1/10), Uncommon (≥1/1,000 to <1/100), Rare (≥1/10,000 to <1/1,000), Very Rare (<1/10,000) and Not known (cannot be estimated from the available data).

Adverse reaction (MedDRA Preferred Term)

System Organ ClassCommonUncommonRare
Immune system disordersHypersensitivity reactionsAngiodema(2)
Nervous system disordersHeadacheDizzinessStroke(1) (including including hemorrhagic events), Syncope, Transient ischemic attacks(1), Migraine(2), Seizures(2), Transient amnesia
Eye disordersBlurred vision, Sensations described as eye painVisual field defect, Swelling of eyelids, Conjunctiva hyperaemia, Non-arteritic anterior ischaemic optic neuropathy (NAION)(2), Retinal vascular occlusion(2)
Ear and labyrinth disordersTinnitusSudden hearing loss
Cardiac disorders(2)Tachycardia, PalpitationsMyocardial infarction, Unstable angina pectoris(2), Ventricular arrhythmia(2)
Vascular disordersFlushingHypotension(3), Hypertension
Respiratory, thoracic and mediastinal disordersNasal congestionDyspnoea, Epistaxis
Gastrointestinal disordersDyspepsiaAbdominal pain, Vomiting, Nausea, Gastro-oesophagael reflux
Skin and subcutaneous tissue disordersRashUrticaria, Stevens-Johnson syndrome(2), Exfoliative dermatitis(2), Hyperhydrosis (sweating)
Musculoskeletal, connective tissue and bone disordersBack pain, Myalgia, Pain in extremity
Renal and urninary disordersHaematuria
Reproductive system and breast disordersProlonged erectionsPriapism, Penile hemorrhage, Haematospermia
General disorders and administration site conditionsChest pain(3), Peripheral oedema, FatigueFacial oedema(2), Sudden cardiac death(1,2)

(1) Most of the patients had pre-existing cardiovascular risk factors.
(2) Postmarketing surveillance reported adverse reactions not observed in placebo-controlled clinical trials.
(3) More commonly reported when tadalafil is given to patients who are already taking antihypertensive medicinal products.

 

Description of selected adverse reactions

A slightly higher incidence of ECG abnormalities, primarily sinus bradycardia, has been reported in patients treated with tadalafil once a day as compared with placebo. Most of these ECG abnormalities were not associated with adverse reactions.

Cialis & Tadalafil (As Needed)

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Other special populations

Data on patients over 65 years of age receiving tadalafil in clinical trials, either for the treatment of erectile dysfunction or the treatment of benign prostatic hyperplasia, are limited. In clinical trials with tadalafil taken on demand for the treatment of erectile dysfunction, diarrhoea was reported more frequently in patients over 65 years of age. In clinical trials with tadalafil 5 mg taken once a day for the treatment of benign prostatic hyperplasia, dizziness and diarrhoea were reported more frequently in patients over 75 years of age.

 

Reporting of suspected adverse reactions

Reporting of all suspected adverse reactions is important. It allows for continued monitoring of the benefit/risk balance of the medicinal product. Healthcare professionals and patients are asked to report any suspected adverse reactions via the Yellow Card Scheme.
You can find out more information about the Yellow Card Scheme by clicking here.

 

Is there anything else I need to know about Cialis?

Cialis may be taken on an empty stomach or after eating a meal.
A physical examination may be required to diagnose erectile dysfunction or benign prostatic hyperplasia and determine potential underlying causes before pharmacological treatment with Cialis is considered.
Should you develop any sudden visual defects whilst taking Cialis, you need to stop taking Cialis immediately and consult a doctor. You should also stop taking Cialis immediately and speak to a doctor if you experience a decrease in your hearing or experience a complete loss of hearing.
If you experience erections lasting for four hours or more (Priapism), you need to seek medical assistance urgently. If your priapism is not treated immediately, penile tissue damage may occur and there may be permanent loss of potency as a result.
Taking Cialis has little or no influence on one’s ability to drive or use machines. Although the frequency of reports of dizziness in placebo and tadalafil arms in clinical trials was similar, you should be aware of how you react to CIALIS before driving or using machines.

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If you would like more information about Cialis, please click here to fill out our contact form. Alternatively, you can call us on 01625 460 621.
Should you need urgent medical assistance, please dial 999.

 

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References

  1. https://www.medicines.org.uk/emc/product/7431/smpc
  2. https://www.medicines.org.uk/emc/product/7431/smpc#EXCIPIENTS
  3. https://bnf.nice.org.uk/drug/tadalafil.html
  4. https://www.medicines.org.uk/emc/product/7431/smpc#INDICATIONS
  5. https://www.medicines.org.uk/emc/product/7431/smpc#POSOLOGY
  6. https://www.medicines.org.uk/emc/product/7431/smpc#CLINICAL_PRECAUTIONS
  7. https://www.medicines.org.uk/emc/product/7431/smpc#MACHINEOPS

 

Assured Pharmacy is not liable for the currency or accuracy of the information contained in this blog post. For specific information about your personal medical condition, please contact our doctors or pharmacists for advice on [email protected]