Effectiveness Of Levitra

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Ten facts you should know about Erectile dysfunction

Erectile dysfunction can happen for many reasons, like poor blood flow to the penis, nerve damage, hormonal issues. medication side effects or psychological and emotional issues.
When suffering from erectile dysfunction, you should adopt healthy lifestyle behaviours, such as being physically active, quitting smoking and following a healthy eating plan.
It is normal for men to have erectile dysfunction occasionally, but if it happens a lot, it may require medical intervention.
The UK was the first to have the initiative of incorporating erectile dysfunction as an independent risk factor for cardiovascular disease.
Phosphodiesterase type 5 (PDE5) inhibitors like Avanafil (Spedra), Sildenafil (Viagra), Tadalafil (Cialis), and Vardenafil (Levitra) help increase blood flow to the penis and are considered first-line treatments for the management of ED.


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These drugs are usually the first method patients try, but they should not be used by men who take nitrates.
Patients with slow drug absorption (e.g., Parkinsonian patients) may need to wait 2-3 hours for an erection to develop after taking PDE5 inhibitors.
Atherosclerosis (hardening of the arteries), high cholesterol or high blood pressure are major contributors to the subsequent development of Erectile dysfunction.
Men can have erectile dysfunction at any age, but it happens more frequently in middle-aged men.
Medications for treating ED are available for more than 20 years.
Medications for treating Erectile, what’s the difference?
Viagra is the pioneer drug for the treatment of ED discovered 20 years ago, in 1998, that is used only when needed. The drug is taken 30 minutes to 1 hour prior to sexual activity, and the effects typically last for 3-5 hours.
Levitra may start working faster than Viagra, but lasts for about the same amount of time.
Cialis is a drug well tolerated that can be used on as needed basis, but also on daily basis.


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Effectiveness of Levitra

Levitra is a drug for the treatment of erectile dysfunction, containing vardenafil.
Levitra was approved and is available on the pharmaceutical market from more than 15 years ago, in 3 different doses: 5, 10 and 20 mg.
Levitra works in the same way as all drugs from the class of PDE5 inhibitors.
This class of drugs helps the muscles to relax and increases blood flow to the body. This makes it easier for blood to get into the penis and allows people with erectile dysfunction to experience a lasting erection during sexual activity.
In order for Levitra to have an effect, sexual stimulation is required.
The recommended starting dose of Levitra is 10 mg taken as needed approximately 25 to 60 minutes before sexual activity.
Based on efficacy and tolerability the dose may be increased to 20 mg or decreased to 5 mg. The maximum recommended dose is 20 mg.
The maximum recommended dosing frequency is no more than once per day.
Levitra can be administrated with or without food but the onset of action may be delayed if taken with a high-fat meal.


Levitra should not be administered in the following cases:

  • If you have hypersensitivity to the active substance, vardenafil
  • If you are in the case of co-administration of vardenafil with nitrates or nitric oxide donors (such as amyl nitrite)
  • If you have loss of vision in one eye because of non-arteritic anterior ischemic optic neuropathy (NAION), regardless of whether this episode was in connection or not with previous phosphodiesterase 5 (PDE5) inhibitor exposure
  • If sexual activity is inadvisable for you (e.g. patients with severe cardiovascular disorders such as unstable angina or severe cardiac failure.
  • If you have a severe hepatic impairment (Child-Pugh C),
  • If you have an end-stage renal disease requiring dialysis,
  • If you have hypotension (decreased blood pressure < 90/50 mmHg
  • If you have a recent history of stroke or myocardial infarction, in the last 6 months
  • If you have unstable angina (chest pain)
  • If you have hereditary retinal degenerative disorders such as retinitis pigmentosa
  • To test its efficacy, Levitra went through a series of clinical trials.

The Real-Life Safety and Efficacy of vardenafil (also known as REALISE study) was an international study in men with erectile dysfunction (ED), conducted with the aim to determine the safety and efficacy of vardenafil in a large international pool of men with ED (aged ≥18 years) and associated underlying conditions, in a real-life setting. For this study 73.946 men agreed to participate.
Data were pooled from 47 countries in Europe, Asia-Pacific, Latin America, and the rest of the world (excluding the United States and Japan for methodological reasons).

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The study participants suffering from ED also had associated underlying conditions, such as hypertension (32.0%), diabetes (22.1%), lipid metabolism disorder (14.6%), or cardiovascular diseases (42.2%).
The treatment with Levitra was administered during a period of 1 year, with a starting dose of 10 mg.
After 1 year, improvements in erectile function following vardenafil treatment were reported by over 90% of patients, regardless of baseline ED severity (mild, 97.0%; moderate, 96.2%; or severe, 85.5%), with the majority of these patients reporting improvement after the first vardenafil intake. Also, 97.0% of patients were either “satisfied” or “very satisfied” with vardenafil tolerability, managing the adverse events.
These data collected from a worldwide population of men with ED prove that vardenafil is an effective and well-tolerated treatment for ED in a real-life setting, supporting its use as a first-line ED therapy.
Previous research has demonstrated the clear association between ED and age-related conditions such as hypertension, diabetes mellitus, lipid metabolism disorder, and cardiovascular diseases.
Therefore, it was really necessary to evaluate the efficacy and safety of ED treatments in these patient populations. The REALISE study is the largest worldwide post-marketing surveillance study conducted to date investigating the efficacy and safety of vardenafil, concluding that vardenafil is the first line treatment for treatment for ED in men with associated underlying conditions.
Patients should be aware that there are several drugs available for the treatment of ED.
If one drug works for you it does not mean that it works for everybody.
Pay attention to side effects and if you cannot manage them, talk to your doctor.


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What if I experience a problem?

Before taking drugs for ED, please carefully evaluate the adverse reactions, reading the patient information leaflet.
A headache can be an unpleasant reaction when using Levitra®
Also, dizziness, flushing, nasal congestion, dyspepsia, palpitation, dyspnoea, tinnitus and vertigo were reported.
Amnesia, syncope, seizure, increases in intraocular pressure and epistaxis were amongst the rare adverse reactions that user reported when consuming Levitra®
In the Patient Information Leaflet, related to adverse reactions observed when administering vardenafil medicinal products, some events appear more frequent and some relatively rare.
If any unpleasant effect appears when taking Levitra®, please address directly to our pharmacy and to our doctor at phone number 01625 460 621.
Please bear in mind that overcoming erectile dysfunction takes time.
Before you decide whether Levitra® is the drug for you, you should consider the risk/benefit ratio and be supervised by a healthcare professional while taking it.

For any questions related to erectile dysfunction or to Levitra® please email us at [email protected]


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  1. http://www.issm.info/sexual-health-qa/what-is-erectile-dysfunction1/
  2. http://www.ema.europa.eu/docs/en_GB/document_library/EPAR Product_Information/human/000475/WC500039992.pdf
  3. Van Ahlen H, Zumbé J, Stauch K, Hanisch JU. The Real-Life Safety and Efficacy of vardenafil (REALISE) study: results in men from Europe and overseas with erectile dysfunction and cardiovascular or metabolic conditions. J Sex Med. 2010 Sep;7(9):3161-9. doi: 10.1111/j.1743-
  4. 6109.2010.01921.x. PubMed PMID: 20646189.
  5. Rosen RC, Fisher WA, Eardley I, Niederberger C, Nadel A, Sand M. The multinational Men’s Attitudes to Life Events and Sexuality (MALES) study: I. Prevalence of erectile dysfunction and related health concerns in the general population. Curr Med Res Opin 2004;20:607–17

Assured Pharmacy is not liable for the currency or accuracy of the information contained in this blog post. For specific information about your personal medical condition, please contact our doctors or pharmacists for advice on [email protected]