Does Spedra Have Side Effects?

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What is Spedra?

Spedra is the trade name given to the drug Avanafil. It belongs to the PDE5 inhibitors class of drugs. Spedra like other PDE5 inhibitors improves the erectile function of men after being sexually stimulated. other drugs belonging to this class are Viagra, Levitra and Cialis.
Spedra was introduced in the market by an Italian Pharmaceutical company Menarini in 2014. The medication is not open in market for generic manufacturing by other companies till 2029. In most cases, branded medications tend to be more expensive than generic ones when multiple brands are available in the market. But it is beneficial in the case of Spedra where no other brand is available, and the customer will get a genuine brand while buying the item online.
Spedra has a distinct physical appearance in terms of tablets. Its tablets have a yellow appearance. The tablets are packed in the specific packaging having the logo of the Menarini company. Therefore, if there is any medicine being sold in the market under the name of Spedra having a different packing or unrecognized logo; it is fake.


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Mechanism of Action of Spedra:

Spedra has nothing to do with the sexual arousal of a man. It only works after the sexual arousal of a man.
To understand the working of Spedra it is very much important to understand the mechanism that how a man becomes erect after a sexual stimulus. After getting sexually stimulated, the tissues present in the penis, involved in the process of erection releases nitric oxide (NO). a messenger cyclic guanosine monophosphate (cGMP) is released by the enzyme. This specific enzyme is activated by nitric oxide chemical released in the body. The cyclic Guanosine Monophosphate causes the relaxation of the smooth muscles causing the dilation of the arteries in the penis. The increased dilation causes the increased blood flow into your penis. The erectile tissue fills with blood and causes the erection of the penis.
Spedra inhibits the phosphodiesterase type 5 enzyme, found in many organs of the body but specifically present in the corpus cavernosum in the penis. The level of cGMP is maintained in the smooth muscle cells by the phosphodiesterase enzyme. But if a person is not stimulated sexually then there will be an absence of nitric oxide release by the brain, thus an absence of cGMP.


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Why choose Spedra?

There are various drugs available in the market for the treatment of erectile dysfunction. every drug has its own specific characteristics. In this article, we will consider the properties associated with Spedra.

There are various benefits of Spedra that makes the drug a better choice as compared to other drugs of the same class.
A major benefit associated with Spedra is the duration of action of the drug. Most of the drugs belonging to this class take 30-60 minutes to give desirable results in patients of erectile dysfunction. whereas, Spedra takes only 15-30 minutes to reach the required therapeutic results. The high speed of action of Spedra is not only the only benefit of this drug.
In clinical trials, various doses of Spedra have proven their efficacy in almost half of the cases.
Various cases are given below showing the percentage of successful intercourses after taking various doses.

  • 50mg dose of Spedra has reported a 47% success rate
  • 100mg dose showed a 58% success rate
  • A 59% success rate is reported at a dose of 200mg

Furthermore, a study has shown that at 24.7% and 28.1% of people after using the 100mg and 200mg dose of Spedra respectively shows an increased time of intercourse for up to 15 minutes after administration.


When not to use Spedra?

Like a general concept, every medicine is not suitable for everyone. It should be used with caution in a few persons.

  • Men having an allergy to Avanafil or other ingredients in Spedra
  • Males under the age of 18 years
  • Men taking medicines belonging to the nitrates group of medicines like HIV, AIDS, Antifungal and certain other medication after consulting the physician.
  • In case of having organ dysfunction
  • Having a previous history of heart, vascular diseases or eye problems

Spedra interacts with a few medicines. Therefore, it is very much important to discuss with your doctor, if you are taking any other medicine along with Spedra to avoid side effects and other problems.
Spedra is also prohibited for women. It may cause dizziness, blurred vision, fatigue. It is advised to avoid the traffic if you are suffering from any of these side effects.
alcohol should be avoided with Spedra because it intensifies the problems like dizziness, impairing the ability to get an erection for a certain period.
Patients are advised to reduce or limit drinking Alcohol to get maximum effect from the drug.


Side Effects of Spedra:

There are various side effects of Spedra, but these are usually mild and are for a short duration. The recommended dose of Spedra to avoid side effects is 100mg to be taken approximately 30 minutes before the sexual intercourse. The dose can be increased to a maximum of 200mg or can be reduced to 50mg. The variation in dose is dependent on an individual’s capacity to tolerate.
Various side effects of Spedra are:

  • Nasal congestion
  • Dizziness
  • Fatigue
  • Sleepiness
  • Eye problems
  • Blurred vision or certain other eye problems
  • Consult your physician, if side effects are severe or are persistent for a long duration.


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Drug interaction of Spedra with other Drugs:

Various drugs interact with Spedra. Although the list below is not complete and it’s better to consult a physician about all your prescription and non-prescription medicines. Listed below are few drugs that should be taken with caution.

  • Nitrate medications (nitro-glycerine, isosorbide mononitrate or dinitrate, glyceryl trinitrate)
  • Sodium nitroprusside
  • Cimetidine
  • Erythromycin
  • Antifungal drugs like Ketoconazole and Itraconazole
  • Mibefradil
  • Rifampicin
  • Alpha blockers, (taken for prostate gland diseases and high blood pressure)
  • Ritonavir
  • Amyl, Propyl and Butyl nitrates

Before taking any medicine, it is better to read the drug formation sheet that comes in the packaging of the drug.


How to reduce the risks of Spedra side Effects:

  • Recreational drugs:
    Avoid using recreational drugs. Various recreational drugs can cause serious side effects or reactions. For effective results and to avoid side effects avoid them completely.
  • Alcohol:
    Drinking more units of alcohol can alter the onset and duration of action of Spedra. Similarly, the tendency to side effects can also be increased.
  • Lowering the dose of medicine:
    Taking a lower dose of medicine reduces the risk of side effects. Before changing a prescribed dose, it is very much important to consult the doctor.
  • Avoid medicine intake with food:
    Spedra shows a maximum therapeutic effect when taken on an empty stomach. A positive point associated with concurrent intake of food and Spedra is reducing the possibility of side effects, but it will slow down the effectiveness of drug.
  • Interaction of prescription medicine with Spedra:
    Spedra influences the cardiovascular system. Some prescription medicines usually do not interact with Spedra. This may increase the risk of side effects and may lead to fatal results. If a person is taking any of the cardiovascular drugs, he should properly consult the physician via patient record to ensure the safety.



Spedra is a targeted drug used for the treatment of erectile dysfunction and is proven clinically as an effective drug. It has a fast mode of action working in less than 20 minutes in men. It is also recommended widely by doctors due to its fewer side effects.


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Assured Pharmacy is not liable for the currency or accuracy of the information contained in this blog post. For specific information about your personal medical condition, please contact our doctors or pharmacists for advice on [email protected]