Those of you who desire to use medication for erectile dysfunction or just to have better erections would be overwhelmed and confused with the various options available in the market. Some of the most commonly used drugs approved for erectile dysfunction include; Viagra (Sildenafil), Cialis (Tadalafil), Spedra (Avanafil) and Levitra (Vardenafil). Here again, those of you who have tried Viagra or Cialis would be curious to know the effectiveness of Spedra! This blog would address one key factor that favours Spedra (Avanafil) in comparison to the others… Spontaneity!
The phosphodiesterase type 5 (PDE5) inhibitors & penile erection
Almost all the drugs approved for erectile dysfunction (Viagra, Cialis, Spedra and Levitra) belong to the same class of medication known as the phosphodiesterase type 5 (PDE5) inhibitors and therefore share the same mechanism of action through which they provide firm penile erections.
In general, sexual stimulation causes the local release of nitric oxide (NO) in the corpus cavernosum (erectile tissue forming the bulk of the penis). Nitric oxide (NO) then activates the enzyme guanylyl cyclase, which results in increased levels of cyclic guanosine monophosphate (cGMP). The increased levels of cGMP in the corpus cavernosum produce smooth muscle relaxation and inflow of blood into the penile tissues, thereby producing an erection. Phosphodiesterase type 5 (PDE5) degrades cGMP in the corpus cavernosum, and when PDE5 is blocked, this increases blood flow to the penis, which in turn will, in most cases, result in an erection. It should be noted here that all these drugs maintain increased levels of cGMP in the corpus cavernosum.
Although the agents discussed above belong to the same drug class, they do not share the same basic ingredient (chemical composition) and therefore there are some key differences between them in terms of onset of action (how quick they work) side effect profiles, and duration of action (how long the drug effect lasts). Let’s take a closer look at Spedra (Avanafil) before we do a comparison with the other drugs for erectile dysfunction.
Spedra (Avanafil) for erectile dysfunction
Avanafil (Spedra) has been evaluated in many clinical trials comprising ‘12 weeks’ treatment in men with ED (mean age of 55), including men with diabetes or after prostatectomy (surgical removal of part or all of the prostate gland). These clinical trials included men with mild to severe erectile dysfunction (ED) including those with an inability to achieve vaginal penetration during sexual intercourse without medication.
One such clinical trial (12-week) indicates that, of a total of 600+ men who were randomly assigned to take 50, 100, or 200 mg of Avanafil (Spedra) 30 minutes before initiating sexual activity, about 63% to 72% were successful in having firm erections and successful intercourse compared with men who took placebo(no drug). The results also indicate that attempts at sexual intercourse made more than 6 hours after taking Spedra were successful compared with attempts in men who took a placebo, indicating that the drug has a longer duration of action and in some men, Spedra worked in as little as 15 minutes indicating a rapid onset of action. Here again, in men with erectile dysfunction related to diabetes about 57% achieved an erection after taking Spedra compared with those who took a placebo.
The results of these trials concluded that many of those treated with Avanafil (Spedra) had firm erections; resulting in successful intercourse in comparison to placebo. The percentage of attempts with successful vaginal penetration was satisfactory with Avanafil (Spedra) 50, 100 or 200mg.
One key factor that may separate Spedra (Avanafil) from the other drugs for erectile dysfunction is its onset of action (how fast it works). Though there is no direct comparison among the various drugs available to treat erectile dysfunction, Spedra is known to be the fastest acting with clinical trials indicating that it can work as fast as 15 minutes.
Spontaneity in sexual intimacy
Spontaneity is the gold standard when it comes to sexual intimacy. The time frame is important. Spontaneity here means to get the desired response from the medication in a quick time and for the duration required. Spedra with its rapid absorption and selectivity profile has a rapid onset of action (15 minutes) that could provide spontaneity in sexual intercourse for men who suffer from erectile dysfunction or just prefer medication for better and firm erections.
There are some very rare side effects associated with all erectile dysfunction drugs and this holds true for Spedra as well. This includes sudden loss of hearing in one or both ears and colour vision changes. It is advised to contact the healthcare provider if you experience any of these side effects.
Clinical studies with Spedra in healthy volunteers showed side effect or adverse events that were similar to other drugs in this class (Viagra, Cialis, and Levitra) but the incidence rates and severities of the adverse events were increased with overdosage. Overdose with Spedra may result in priapism which refers to the persistent and painful erection of the penis. It is advisable to report any erections persisting for more than 4 hours to a physician. Applying ice may initially help until the person reaches a physician’s office but a urologist should be consulted as soon as possible, especially if the erection has been present for many hours. If priapism is not treated immediately, penile tissue damage and/or permanent loss of potency may result.
As with all PDE5 inhibitors, Spedra (Avanafil) has been shown to potentiate the hypotensive effects of nitrates which are a class of medication prescribed to treat angina (chest pain) and is therefore contraindicated in patients who are taking any type of nitrate drug therapy, or who utilize short-acting nitrate-containing medications, due to the risk of developing potentially life-threatening hypotension. The use of organic nitrates, either regularly and/or intermittently, in any form (e.g. oral, sublingual, transdermal, by inhalation) is absolutely contraindicated. Here again, treatments for erectile dysfunction should not be generally used in men for whom sexual activity is inadvisable. This includes people with heart problems, such as heart attack, angina, heart failure, irregular heartbeat, heart surgery within the last 6 months, Stroke, Low or high blood pressure, Retinitis pigmentosa (a genetic eye disease), bleeding problems, stomach ulcers, liver problems, kidney problems, or any other medical conditions
Spedra (Avanafil) is an excellent drug of choice among the PDE5 inhibitors available to treat erectile dysfunction and when used in appropriate, recommended doses increases the ability of couples’ to have satisfactory sexual intercourse. If you are looking for sexual intimacy with spontaneity then Spedra should be your best choice!
CTC – Canada
Clinical trials – ncbi.nlm
Rx Prep USA
APhA – drug information
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