A Brief History Of Viagra

March 27, 1998- the day that Viagra was introduced to the world. Up until this date, men around the world suffering from erectile dysfunction had very few feasible options to help treat their condition. To understand just how the introduction of the Viagra changed the face of erectile dysfunction treatment, it is first worth taking a look at treatments that were used up until the introduction of the ‘wonder pill’.

It is believed that around 50% of men suffer from erectile dysfunction at some point in their lives, but it has only been in the last two decades that effective, accessible treatment has been on the market. Put it this way, it was just 100 years ago that putting electric shocks through the penis was seen as a viable way of treating the condition.

Until the 1980s, it was postulated that difficulty achieving and maintaining erections was caused by anxiety. This led to psychotherapy becoming a primary source of treatment, with counseling sessions and therapy used as ways of trying to address the anxiety. A major drawback with the introduction of psychotherapy is that it led to men becoming embarrassed and afraid to seek help for their condition. Some men saw it as a kind of weakness that took away from their masculinity and instead tried to address the situation on their own, often unsuccessfully.

A Brief History Of Viagra
Therapy

The 1980s saw a move away from psychotherapy and more of a focus on treating the physical causes behind erectile dysfunction. Self-injection was introduced and is still used to this day. Phentolamine and alprostadil can both be injected into the penis to stimulate erections.

However, using injections comes with some major side effects. The physical trauma caused by the needle often causes a dull ache and can even result in scarring. Furthermore, administering drugs straight into the penis gives a potent effect, and can stimulate erections that last far too long (sometimes over 4 hours).

It therefore came as little surprise that Viagra, the first tablet that was able to safely and effectively address the physical causes of erectile dysfunction, became the fastest selling drug of all time. Remarkably, this little blue pill that is still so popular today was actually discovered by accident. Viagra began its life as a plain, relatively unspectacular tablet known by its trial code of ‘UK92480’. It was designed by the pharmaceutical company Pfizer to treat a completely different condition involving chest pain, known as angina. UK92480 was found to have little effect in relieving chest pain, and Pfizer were on the verge of completely abandoning production of the drug.

However, reports began to show a distinctive pattern; a very large proportion of the male trial subjects were experiencing an unusual side effect. You’ve probably guessed what this mysterious side effect was by now, but I’ll tell you anyway- the men were experiencing erections.

Sildenafil-100-4Realising that there was a gaping hole in the market for an oral erectile dysfunction treatment, Pfizer pursued the development of the drug, known as sildenafil citrate, and gave it the brand name ‘Viagra’. Further trials followed, this time with a focus on treating erectile dysfunction as opposed to angina. The FDA approved Viagra in 1998 and the drug proved to be a huge success, demonstrated by the fact that it reached sales of close to $2 billion by 2008.

So, just how does Viagra work? First of all, it helps to look at what the drug was initially designed to treat in order to understand its mechanism of action. As aforementioned, angina is caused by restricted blood flow to the heart muscles. Similarly, erections are prevented when there is restricted blood flow to the penis. From here, it becomes easier to see why a drug designed to alleviate chest pain by dilating blood vessels ended up giving men erections; the blood vessels of the penis became dilated instead.

Viagra produces this effect by inhibiting the production of an enzyme in the body called phosphodiesterase type 5. It all sounds very complex but this basically causes muscles in the blood vessel walls of the penis to relax, allowing more blood to flow through. The increased blood flow allows the penis to become rigid for a prolonged period of time, which helps explain why Viagra is able to stimulate erections. The chemical messengers in the body that Viagra enhance only exert their effect upon sexual stimulation. Viagra therefore only causes an erection once an individual has already been sexually stimulated.

A Brief History Of Viagra
Safe Sex

Viagra is an easy drug to use; one tablet simply needs to be taken 1 hour before intercourse. Furthermore, the tablet is small, making it easy to swallow. Within a window of between 30 minutes and 4 hours after taking the medicine, it becomes easier to maintain an erection. The standard recommended dosage for Viagra is 50mg, although this can be increased up to 100mg or reduced to 25mg depending on efficacy/side-effects. Some side-effects associated with Viagra include headache, dizziness and flushing. However, such effects are fairly uncommon and usually pass within a short space of time.

Viagra is a very safe drug, and this safety combined with its ease of use both help contribute to its popularity. Despite this, it can interact with a range of other medicines, so it is important that a doctor prescribes the drug.

If you suffer from erectile dysfunction, you can buy Viagra or its unbranded form sildenafil here at Assured Pharmacy. Upon completion of an online questionnaire, a GMC regulated doctor will issue a prescription that allows you to acquire Viagra in an efficient, safe and regulated manner. This prescription is sent directly to our pharmacy where it is checked by a qualified pharmacist to ensure the treatment is suitable. Customers who have purchased Viagra from Assured Pharmacy have rated their experience as ‘excellent’.

We strive to provide a safe, high quality service at a good price. Whatever you choose to do, please don’t suffer in silence. Erectile dysfunction is an extremely common issue, and nothing to feel embarrassed or ashamed about. If you would like to speak to someone in confidence or find out more information about the products we offer, please call 01625460621 or e-mail [email protected].

 

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References

http://www.mirror.co.uk/news/world-news/how-doctors-treat-impotence-before-7530711
https://www.sharecare.com/health/male-reproductive-medications/erectile-dysfunction-before-viagra
https://www.urologicalcare.com/erectile-dysfunction/penile-injection-therapy/
http://news.bbc.co.uk/1/hi/health/8466118.stm
https://www.drugs.com/slideshow/viagra-little-blue-pill-1043
http://www.netdoctor.co.uk/medicines/sexual-health/a7733/viagra-sildenafil/

 

Assured Pharmacy is not liable for the currency or accuracy of the information contained in this blog post. For specific information about your personal medical condition, please contact our doctors or pharmacists for advice on [email protected].

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