Viagra (Sildenafil) Research – Studies on the Wonder Drug

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Viagra; considered to be a major medical breakthrough and a medicine wonder of the 21st century. Indeed, sales of Viagra are shocking, to say the least, with annual sales reports hitting the billion-dollar mark and it is, therefore, no wonder that Viagra is now considered to be among the highest money grossing prescription drugs ever produced by Pfizer since its approval in 1998. But is the Viagra hype really justified?

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Viagra can alleviate these symptoms by acting as a selective and potent inhibitor of cyclic guanosine monophosphate (cGMP) specific phosphodiesterase type 5 in the corpus cavernosum (an area of the penis primarily responsible for obtaining erections). Viagra works by increasing the levels of nitric oxide in the corpus cavernosum which increases blood flow to the penis, thereby increasing rigidity.

Sexual stimulation is essential for Viagra to exhibit its desired effects.

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How Common is Erectile Dysfunction

Diabetes and ViagraIt’s important to realise that erectile dysfunction/male impotence is a common condition, affecting around half of the men over the age of 40 years. Furthermore, as with increasing age, certain medical conditions can further increase the likelihood of a man experiencing erectile dysfunction, examples include hypertension, diabetes type one or two, neurological conditions such as depression and physical injuries such as those to the spine.

As shown by sales figures, for many men Viagra can prove an invaluable help-line in treating symptoms of male impotence and aid the path to a healthy and happy relationship which can otherwise be hindered by this condition. But how good really is it?

How Effective Is Viagra?

Since its approval in 1998 Viagra has been experimented with in over 100 clinical trials involving thousands of men. In addition, Viagra is also used as a first-line treatment for erectile dysfunction compared to other drugs within the same pharmacological class including LevitraCialis (containing Tadalafil and Spedra (containing Avanafil), making it the first and most natural choice for doctors and other prescribers.

Getting to the science of how well Viagra works we can relate back to the research conducted in these clinical trials. These studies have been conducted in a wide range of circumstances to investigate and answer the questions surrounding the usage of Viagra.

The first studies to consider are related to how fast Viagra works and how long is the time-window after dosing during which Viagra could produce effects in response to sexual stimuli.

 

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Product Description

How does Viagra and Sildenafil work?

Viagra (Sildenafil) helps men to get and maintain an erection when sexually stimulated and/or excited. The medicine relaxes the blood vessels in the penis which results in more blood flowing to the penis when you are sexually excited.

How do I take it?

You should take Viagra (Sildenafil) approximately 1 hour before planning to have intercourse. Within a window of between 30 minutes and 4 hours after you take the medicine, it will be easier to keep and maintain an erection when you are sexually excited. If you take this medicine after a meal with a high fat content it may take a little longer to start working. This medicine will only work when you are sexually excited. You won’t get an erection just by taking Viagra (Sildenafil).

Dosage

The standard recommended dose for Viagra (Sildenafil) is 50mg and this will be suitable for most people.  If this dose is not effective, you can try 100mg and if 50mg gives you side effects you can also reduce the dose to 25mg tablets.

You must not take more than 100mg daily of Sildenafil/ Viagra. Clinical trials have been conducted in patients taking up to 200mg sildenafil and it was found that ‘doses of 200mg did not result in increased efficacy but did increase the incidence of adverse reactions (headache, flushing, dizziness, dyspepsia, nasal congestion, and altered vision).’

In addition, in patients taking more than 100mg daily, there have been reports of rhabdomyolysis (a breakdown in skeletal muscle tissue the byproducts of which can lead to kidney failure), visual perception changes, vertebral artery dissection (a tear in the artery supplying blood to the brain), heart attacks and aggressive behaviour.

If the 100mg strength doesn’t work for you, there may be alternatives you can try and we recommend that you call us for a free consultation with our pharmacist or doctor to discuss any underlying conditions you may have. We recommend that all men taking medicine for erectile dysfunction have regular tests for blood pressure, cholesterol, diabetes and hormone imbalances. For instance, it may be that by fixing a hormone imbalance such as testosterone, your Viagra medication will be even more effective.

In addition, drug manufacturers do not advise patients to split tablets in half to get the correct dosage as they cannot guarantee that the active ingredient will be distributed evenly throughout the tablet.  For instance, if you cut a 100mg tablet in two, you may find that you get 80mg in one half of the tablet and 20mg in the other half leading to either an overdose (increased risk of side effects) or a suboptimal dose (the medication may not work).

It is important that you choose the correct dose for you. If you wish to talk to our pharmacist or doctor about this, please contact us in the pharmacy on 01625 460621 or email [email protected]

Side Effects

Viagra (Sildenafil) is normally well tolerated, however, side effects can include:

  • Headache
  • Dizziness
  • Nausea

Side effects normally subside after a few hours, however, if you experience a prolonged or painful erection (longer than 4 hours), then you must contact your doctor immediately.

Drug interactions

There are a number of medicines which interact with Sildenafil/ Viagra. For an exhaustive list please see the patient information leaflet (see section below) or call us in the pharmacy to discuss your specific situation. The main drug interactions are listed here:

Recreational drugs such as ‘poppers’ or amyl nitrate
Alpha blockers used for urinary retention or blood pressure problems (eg Flomax or Cardura)
Anti- arrhythmic drugs such as disopyramide
Antibiotics such as erythromycin
Antifungals such as itraconazole
Antivirals such as drugs used to treat HIV
Bosentan
Cobicistat
Calcium channel blockers to treat blood pressure and angina such as amlodipine
Dapoxetine (Priligy – used to treat premature ejaculation)
Grapefruit juice**
Nicorandil
Nitrates
Riociguat
Cimetidine (to treat stomach ulcers)

Please do not take Sildenafil/Viagra if you have taken any of the above drugs within the last 60 days without first consulting with either us in the Pharmacy ([email protected] / 01625 460621) or via email with our doctor [email protected]

**We advise not to take Sildenafil/Viagra with grapefruit juice as the blood concentration of Sildenafil will possibly be increased resulting in side effects.

Patient Information Leaflets

Please click here for the patient information leaflet for Viagra.

For Actavis Sildenafil please see the following leaflets: 100mg, 50mg, 25mg.

Storing Medicines Safely

Please keep your medicine out of the reach of children and store at room temperature.  Unwanted medicine can be disposed of by returning it to any local pharmacy or indeed to us here for us to dispose of it for you.

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Furthermore, as mentioned above, male impotence can happen to any man particularly with increasing age and also in men suffering from certain health problems such as heart disease, but how helpful is Viagra in treating impotence in individuals also suffering from these conditions? Indeed, Viagra research has indicated the effectiveness of Viagra can vary to a certain degree between the men with co-existing health problems. One such study has been conducted in relation to this and involved 8000 patients aged between 19-87 years of age, all of whom had a co-existing illness on top of male impotence. Of the 8000 men who participated in the Viagra research 19.9% were elderly, 30.9% suffered from hypertension, 20.3% had diabetes type one or two, 5.8% had ischemic heart disease, 5.2% suffered from depression, 19.8% had hyperlipidemia (associated with high cholesterol) and the remaining percentage were made up of other less common groups of morbidities such as men who suffered a spinal cord injury or undergone a radical prostatectomy.

From this study it was shown the proportions of men reporting that the Viagra treatment was improving their erections were as follows; 62% from a 25mg dose, 74% from a 50mg dose and 82% from taking a 100mg dose. Furthermore, in relation to these specific subsets of participants with co-existing medical conditions and the percentage of those within each group who experienced alleviation in symptoms were as follows: elderly 67%, hypertension 68%, diabetes 59%, ischemic heart disease 69%, depression 75% and hyperlipidemia 61 %.Safe Viagra Sildenafil In Your hands

These results are extremely promising considering that when compared to volunteers taking a placebo, only 25% reported an improvement in erectile dysfunction symptoms.

What About Side Effects?

Another important aspect of how well a medicine works especially for patients are the potential side effects which they may experience from taking the medication. Indeed, unpleasant or nasty side effects can definitely impair efficacy simply because users are much less inclined to use the medication properly, with some patients eventually stopping taking medication at all. It is important to note that all medicines can cause side effects and not necessarily will every patient experience them.

Confused ManCommon side effects of Viagra include a headache, nausea and indigestion. These side effects can affect approximately one in ten users and are generally considered to be mild to moderate in severity. More severe side effects such as swelling of the lips and dizziness occur in around 1% of all users. In addition, a clinical trial to investigate the side effects of Viagra found that of the 3700 patients aged between 19 to 87 years, only around 2.5% had to discontinue treatment due to adverse reactions. This is especially significant considering that this percentage was extremely close to that of the percentage of patients who had to stop taking a placebo medication due to adverse reactions which was 2.3%.

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Conclusion

Therefore, research into the use of Viagra is extremely promising for men of all ages including those with co-existing medical issues. In addition, side effects are generally mild, with only a small proportion of users having to discontinue treatment.

Could Viagra be useful for you or do you simply want to find out more about this medicine? Visit Assured Pharmacy’s website where you can obtain a prescription from a UK based doctor today and have Viagra sent directly and discreetly to your home from a safe and licensed online pharmacy- so don’t let erectile dysfunction keep you feeling down!

 

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References:

http://www.nhs.uk/conditions/erectile-dysfunction/Pages/Causes.aspx
http://www.medicines.org.uk/EMC/medicine/1474/SPC/Viagra+25mg,+50mg,+100mg/
http://www.medicines.org.uk/emc/medicine/2367
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC115867/

 

Assured Pharmacy is not liable for the currency or accuracy of the information contained in this blog post. For specific information about your personal medical condition, please contact our doctors or pharmacists for advice on [email protected].