What Does Viagra Not Do?

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Viagra is considered to be a magical drug regarding the issue of impotence. It is the most discussed pharmaceutical drug on the market since its launch about 30 years ago. It is basically a muscle relaxant of the arterial walls of the penis. There is no doubt about it that it has changed the lives of people all over the world for the better.

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It is a bit of a surprising fact that Viagra was not discovered for the treatment of erectile dysfunction. it was developed by an American company Pfizer for the disorders of hypertension, angina pectoris and ischemic heart disease.

During the developmental research conducted on this medicine, it got to know that it has little effects on the prevention of angina but more potent side effects associated with it. Later it came to know that the drug has some remarkable effects on penile erection. Therefore, in 1998 for the first time, Viagra was introduced in the market as a treatment of erectile dysfunction in the United States. The drug is considered to be illicit for use if you are not having symptoms of erectile dysfunction. Viagra has become so popular among people suffering from impotence that it has generated a record revenue of about $1.93 billion in the year 2008 for the company.

 

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What is the mechanism of action of Viagra?

The active ingredient of Viagra is Sildenafil Citrate. Sildenafil or Viagra inhibits the degradation of cyclic guanosine monophosphate cGMP by inhibiting the catalytic PDE5 enzyme in the corpus cavernous. The basic pathway of penile erection is that the nitric oxide present in the corpus cavernosum of penis binds to receptors named guanylate cyclase resulting in increased levels of cGMP, which leads to smooth muscle relaxation of the internal arteries. The smooth muscle relaxation causes the increased blood flow into the tissues of the penis leading to an erection.

Viagra is a selective inhibitor of cGMP specific phosphodiesterase type 5. PDE5 is basically responsible for the breakdown of cGMP in the corpus cavernosum and its effect is blocked by the intake of Viagra due to the competitive blocking of the receptors. This blocking of the PDE5 results in the more cGMP accumulation and thus better erections. The only limitation to Viagra is the need of proper sex stimulus to activate the NO release, otherwise, no effect will be achieved. Other such PDE5 inhibitors are Tadalafil, Vardenafil.

The elimination of Viagra takes place via hepatic metabolism using cytochrome p450 enzyme for the breakdown. Viagra after metabolization forms a product called N-demethylated sildenafil and is further metabolised by other isoenzymes of cytochrome p450. These metabolites are responsible majorly for the action of Viagra. The drug is excreted from the body through the faecal route of elimination and a small quantity in urine.

The maximum concentration of Viagra is available in the body at least after an hour of intake. The efficacy of the drug is increased if taken with a low-fat diet.

What are the clinical significances of Viagra?

Erectile dysfunction:

It is the inability of a male to get an erection prior to sex or maintaining an erection during the intercourse. Viagra helps men to get an erection after getting stimulus from their sex partner. Viagra helps in relaxing the muscles of the penis thus causing the penis to get erect for a longer duration of time.

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Premature Ejaculation:

Premature ejaculation is also a very common problem prevailing in the male population. The person diagnosed with this problem has an inability to maintain an erection during sex for more than two minutes. The person ejaculates before the completion of the sexual act.

This can be a really embarrassing situation for the man and it may cause unnecessary pressure on the person. The frustration may lead to even a disparity between the couple.

Viagra has a potential ability to treat this problem. Most of the preliminary researches appear to be positive, proposing that Viagra can be helpful in treating premature ejaculation leading to successful completion of the sexual act satisfying the need of the couple.

However, Viagra is not officially approved to treat the problem. Priligy, another PDE5 inhibitor is specifically developed for the treatment of premature ejaculation.

 

What does Viagra not do?

There is no other opinion about it that Viagra has changed the life of many people and it is becoming a popular thing day by day. With every passing day, people are ascribing hopes with the drug which may not even relate to its mechanism of action. A major population of men considers Viagra as a wonder drug and try to find the answer to every sex-related question in Viagra. Well, this thought is not good at all for the health of a person. Most of the times the reason may need another medical treatment rather than Viagra. So, it is important to understand that Viagra is not a solution to every sex-related issue and should be used only according to the advice of the doctor.

It is important to discuss here that Viagra can help in many ways but even then there are a few limitations. Listed below are few medical problems, the treatments of which are associated with Viagra, although it has nothing to do with it.

 

 

Viagra does not increase libido:

A sexual relationship is dependent on a series of associated feelings. Libido is one of them. A decreased libido means a low sex drive. There may be several underlying reasons that lead to a reduced libido. Many people think that viagra can increase the libido while in reality, it has nothing to do with the libido. It is better to find the basic a cause of this problem instead of depending on Viagra. It will never increase your sexual urge.

 

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Viagra also has side effects:

Viagra is considered a very safe medication. Though to some extent, it is true but Viagra also has side effects. Like every other drug, Viagra also has pros and cons. It is very important to consider the side effects and contraindications if you are taking other medications along with Viagra. For example, the hypertensive and cardiac drugs may have severe contraindications with Viagra.

 

Viagra does not lead to immediate erection:

Some men believe that a sudden erection will happen immediately after taking the tablet. It is not possible at all even after taking Viagra. A proper sexual stimulus from your partner is needed to get an erection. Viagra is just a helper in getting a better erection but it cannot start the erection. Just like routine sex relation a proper foreplay is needed to start the procedure of erection. Viagra has nothing to do with starting the erection as well as take time to start the effect just like any other drug.

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Viagra cannot eradicate the underlying causes of ED:

It is a completely wrong perception that Viagra is a solution to every problem. Erectile dysfunction may be due to an underlying cause like cardiovascular disorder, diabetes, a physical injury or even a psychological disorder. In such a situation the Viagra will not be effective at all. So, it very important to find the underlying cause of the erectile dysfunction. the treatment for these problems are different and have to be diagnosed and treated by a medical practitioner.

 

Viagra cannot interfere with the natural process of sex and intercourse:

Viagra does not turn people into a sex machine. It is a common perception among people that after taking the medication a man gets erect within a few minutes and can-do sex for hours without stopping. It is completely wrong. It should be made clear here that long erections are very painful for the man. In fact, it is a disease called priapism. Viagra does not cause ejaculation or help in achieving orgasm. Even after taking Viagra the ejaculation will take place in a normal way. It can neither increase or decrease the natural way of coming out.

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Viagra does not affect you psychologically or emotionally:

Some women blame Viagra for affecting the decisions regarding sex. Although it is a complete misconception. When and with whom to do sex is a person’s own decision. Viagra does not interfere with such decisions at all. Viagra has nothing to do with the emotional intimacy of a person. Even cheating on his wife is a person’s sole choice. Blue pill does not force it to do anything.

 

Protection against sexually transmitted diseases:

A very dangerous misconception is that Viagra is able to protect against sexually transmitted diseases. While using Viagra men stop using protection thinking that it will protect against HIV and other STDs. To have protection like the condom is necessary to avoid disease and unwanted pregnancy, Viagra will do nothing.

 

An increased dose cannot prolong the effect:

As already mentioned above that Viagra cannot interfere with the normal sex procedure. A bigger dose of Viagra cannot prolong the erection effect. A proper dose according to the body need is adjusted by the physician and should not be changed without the advice of a doctor. Some men think that an increased dose will work more for them and increase the pleasure. But it will only result in side effects due to overdose. Increased dose does not influence the action of the drug. Viagra only functions as a vasodilator by preventing the enzyme responsible for contraction of blood vessels. This effect makes the vessels relaxed for a few hours. An increased dose can result in extreme dilation leading to problems instead of being beneficial for the user.

It is no harm in taking Viagra to enhance your sex life after consulting your doctor or pharmacist. However, it is of prime importance to know the pros and cons of the drug. Viagra is not responsible for every sex-related problem or its solution. Viagra is just a medication having its specified therapeutic limits just like any other drug. Try to use it only for what it is specified. It is necessary for your health.

 

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References:

  1. https://www.medicalnewstoday.com/articles/232912.php
  2. https://www.viagra.com/learning/what-are-possible-side-effects
  3. https://beta.nhs.uk/medicines/sildenafil-viagra/
  4. https://www.everydayhealth.com › Erectile Dysfunction

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